Document Type : SI: Biomaterials in Women´s Health
Clinica Mencía Salamanca, Ronda del Corpus, 41, Salamanca 37002, Spain
The prevalence and incidence of Human Papillomavirus (HPV) infection rates are highest among sexually active young women. Pregnancy is regarded as a mild immunosuppressed and hormonally altered state that is a risk factor for HPV infection, viral persistence, and the development of high-grade squamous intraepithelial lesions (HSIL), which is a prerequisite for invasive cervical cancer development. Importantly, HPV infection and surgical treatments of HPV-related lesions are risk factors for perinatal miscarriage and thus, guidelines such as the Spanish Association of Cervical Pathology and Colposcopy (AEPCC) do not recommend the excisional treatment of histologic HSIL (CIN 2 or CIN 3) in pregnant women. As a consequence, conservative, non-invasive and safe treatments for pregnant women are an unmet medical need that must be addressed. Here we report the clinical case of a 26-year-old pregnant woman diagnosed with histologic HSIL, and a positive PCR test for HPV serotypes number 31, 39, and 45. The patient was treated daily with a Coriolus Versicolor-based vaginal gel (Papilocareâ) for 21 days, followed by a 7-day resting period, and 2 months of treatment on alternate days. The patient was able to carry her pregnancy to term and had a vaginal birth without complications. Six months postbirth, cytology showed a regression from HSIL to low-grade squamous intraepithelial lesions (LSIL), and a new PCR test showed HPV negativized in two serotypes, with only type 45 remaining.