Cell Membrane-Coated Biomaterials for Bone Cancer-Targeted Diagnosis and Therapy: A Critical Update on Osteosarcoma Applications

Document Type : Review Article

Authors

1 Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal

2 REQUIMTE/LAQV, Group of Pharmaceutical Technology, Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal

3 Immunology Board for Transplantation And Cell-based Therapeutics (Immuno_TACT), Universal Scientific Education and Research Network (USERN), Tehran 7616911319, Iran

4 Department of Biology, Yadegar-e-Imam Khomeini Shahr-e-Rey Branch, Islamic Azad University, Tehran 181516311, Iran

5 Division of Chemical Biology and Medicinal Chemistry, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina, 27599, USA

6 Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo-14214, NY, USA

7 Health Sciences Research Centre (CICS-UBI), University of Beira Interior, Av. Infante D. Henrique, 6200-506 Covilhã, Portugal

8 School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China

Abstract

Cancer is a malignant disease of increasing concern on account of its high heterogeneity, high mortality and morbidity rates, as well as absence of targeted and effective therapeutic regimes. The recent introduction of biomimetic and nature-inspired principles in the development of nanosystems has significantly impacted cancer therapies and diagnosis. Biomembrane-surface engineered nanosystems are bioinspired nanoconstructions equipped with cell-mimicking features to improve in vivo interactions with surrounding biological environments and cells. These next-generation nanosized delivery systems can enhance therapeutic efficacy and safety of conventional cancer therapies by providing highly specific, targeted, and safer nanomedicines. Herein, we have discussed the unique features of cell membrane-coated biomimetic nanodevices (including superior biocompatibility, immune evasion and tissue-homing features) that allow for promising osteosarcoma-targeted diagnosis, therapy, and theranostics. We also summarized the recent advances on cell membrane- and hybrid cell membrane-coated nanosystems for both primary bone cancer and metastatic scenarios, especially prostate cancer-derived bone metastases. Future perspectives and challenges towards successful clinical translation are also highlighted.

Graphical Abstract

Cell Membrane-Coated Biomaterials for Bone Cancer-Targeted Diagnosis and Therapy: A Critical Update on Osteosarcoma Applications

Keywords

References

 [1] Farnaz Dabbagh Moghaddam FRB. Application of Microfluidic Platforms in Cancer Therapy. Mater Chem Horizons.
2022;1:69-88.
[2] Hu X, Saravanakumar K, Sathiyaseelan A, Rajamanickam V, Wang M-H. Cytotoxicity of aptamer-conjugated chitosan
encapsulated mycogenic gold nanoparticles in human lung cancer cells. J Nanostructure Chem. 2021;12:641-53.
[3] Ahsan F, Yar M, Gulzar A, Ayub K. Therapeutic potential of C2N as targeted drug delivery system for fluorouracil and
nitrosourea to treat cancer: a theoretical study. J Nanostructure Chem. 2022. https://doi.org/10.1007/s40097-022-00474-5.
[4] Gulla S, Lomada D, Araveti PB, Srivastava A, Murikinati MK, Reddy KR, et al. Titanium dioxide nanotubes conjugated with quercetin function as an effective anticancer agent by inducing apoptosis in melanoma cells. J Nanostructure Chem. 2021;11:721-34.
[5] Barani M, Mukhtar M, Rahdar A, Sargazi S, Pandey S, Kang M. Recent Advances in Nanotechnology-Based Diagnosis and Treatments of Human Osteosarcoma. Biosensors. 2021;11.
[6] Zhao X, Wu Q, Gong X, Liu J, Ma Y. Osteosarcoma: a review of current and future therapeutic approaches. Biomed Eng Online. 2021;20:24.
[7] Tan G, Xu J, Yu Q, Yang Z, Zhang H. The safety and efficiency of Photodynamic therapy for the treatment of osteosarcoma: a systematic review of in vitro experiment and animal model reports. Photodiagnosis Photodyn Ther. 2022;1:103093.
[8] Jung JH, Huh KH, Yong TH, Kang JH, Kim JE, Yi WJ, et al. Differentiation of osteosarcoma from osteomyelitis using
microarchitectural analysis on panoramic radiographs. Sci Rep. 2022;12:12339.
[9] Moukengue B, Lallier M, Marchandet L, Baud'huin M, Verrecchia F, Ory B, et al. Origin and Therapies of Osteosarcoma.
Cancers. 2022;14:1-12.
[10] Shoaib Z, Fan TM, Irudayaraj JMK. Osteosarcoma mechanobiology and therapeutic targets. Br J Pharmacol. 2022;179:201- 17.
[11] Yu B, Xue X, Yin Z, Cao L, Li M, Huang J. Engineered Cell Membrane-Derived Nanocarriers: The Enhanced Delivery System for Therapeutic Applications. Front Cell Dev Biol. 2022;10:844050.
[12] Nasim Movagharnezhad SE, Peyman Najafi Moghadam. Synthesis of Poly(N-vinylpyrrolidone)-grafted-magnetite
bromoacetylated cellulose via ATRP for Drug Delivery. Mater Chem Horizons. 2022;1:89-98.
[13] Babaei M, Azar PA, Tehrani MS, Farjaminezhad M, Hussain SW. Green and simple synthesized graphene/MnO2 quantum dot nanocomposite: characterization and application as an efficient adsorbent for solid-phase extraction of heavy metals. J Nanostructure Chem. 2021;12:249-61.
[14] Ding Y, Wang Y, Hu Q. Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy. Exploration. 2022;2:20210106.
[15] Li Y, Gan Y, Li C, Yang YY, Yuan P, Ding X. Cell membrane-engineered hybrid soft nanocomposites for biomedical
applications. J Mater Chem B. 2020;8:5578-96.
[16] Fang RH, Kroll AV, Gao W, Zhang L. Cell Membrane Coating Nanotechnology. Adv Mater. 2018;30:e1706759.
[17] Lopes J, Lopes D, Pereira-Silva M, Peixoto D, Veiga F, Hamblin MR, et al. Macrophage Cell Membrane-Cloaked
Nanoplatforms for Biomedical Applications. Small methods. 2022:e2200289.
[18] Pereira-Silva M, Santos AC, Conde J, Hoskins C, Concheiro A, Alvarez-Lorenzo C, et al. Biomimetic cancer cell membranecoated nanosystems as next-generation cancer therapies. Expert Opin Drug Deliv. 2020;17:1515-8.
[19] Liu H, Miao Z, Zha Z. Cell membrane-coated nanoparticles for immunotherapy. Chin Chem Lett. 2022;33:1673-80.
[20] Malhotra S, Dumoga S, Singh N. Red blood cells membrane-derived nanoparticles: Applications and key challenges in their clinical translation. Wiley Interdiscip Rev Nanomed. 2022;14:e1776.
[21] Han H, Bartolo R, Li J, Shahbazi MA, Santos HA. Biomimetic platelet membrane-coated nanoparticles for targeted therapy. Eur J Pharm Biopharm. 2022;172:1-15.
[22] Wang M, Xin Y, Cao H, Li W, Hua Y, Webster TJ, et al. Recent advances in mesenchymal stem cell membrane-coated
nanoparticles for enhanced drug delivery. Biomater Sci. 2021;9:1088-103.
[23] Ferreira-Faria I, Yousefiasl S, Macario-Soares A, Pereira-Silva M, Peixoto D, Zafar H, et al. Stem cell membrane-coated
abiotic nanomaterials for biomedical applications. J Control Release. 2022:174-97.
[24] Sushnitha M, Evangelopoulos M, Tasciotti E, Taraballi F. Cell Membrane-Based Biomimetic Nanoparticles and the Immune System: Immunomodulatory Interactions to Therapeutic Applications. Front Bioeng Biotechnol. 2020;8:627.
[25] Wang C, Wu S. Research update on cell membrane camouflaged nanoparticles for cancer therapy. Front Bioeng Biotechnol. 2022;10:944518.
[26] Lee NH, You S, Taghizadeh A, Taghizadeh M, Kim HS. Cell Membrane-Cloaked Nanotherapeutics for Targeted Drug
Delivery. Int J Mol Sci. 2022;23:2223.
[27] Dhas N, Garcia MC, Kudarha R, Pandey A, Nikam AN, Gopalan D, et al. Advancements in cell membrane camouflaged
nanoparticles: A bioinspired platform for cancer therapy. J Control Release. 2022;346:71-97.
[28] Scully MA, Sterin EH, Day ES. Membrane-wrapped nanoparticles for nucleic acid delivery. Biomater Sci. 2022;10:4378-91.
[29] Zhao J, Ruan J, Lv G, Shan Q, Fan Z, Wang H, et al. Cell membrane-based biomimetic nanosystems for advanced drug
delivery in cancer therapy: A comprehensive review. Colloids Surf B. 2022;215:112503.
[30] Lei W, Yang C, Wu Y, Ru G, He X, Tong X, et al. Nanocarriers surface engineered with cell membranes for cancer targeted chemotherapy. J nanobiotechnology. 2022;20:45.
[31] Choi B, Park W, Park SB, Rhim WK, Han DK. Recent trends in cell membrane-cloaked nanoparticles for therapeutic
applications. Methods. 2020;177:2-14.
[32] Nguyen TDT, Marasini R, Aryal S. Re-engineered imaging agent using biomimetic approaches. Wiley Interdiscip Rev
Nanomed. 2022;14:e1762.
[33] Ronnie H. Fang WG, Liangfang Zhang Targeting drugs to tumours using cell membrane-coated nanoparticles. Nat Rev Clin Oncol. 2023; 20: 33–48.
[34] Rampado R, Caliceti P, Agostini M. Latest Advances in Biomimetic Cell Membrane-Coated and Membrane-Derived
Nanovectors for Biomedical Applications. Nanomaterials. 2022;12:1543.
[35] Imran M, Jha LA, Hasan N, Shrestha J, Pangeni R, Parvez N, et al. "Nanodecoys" - Future of drug delivery by encapsulating nanoparticles in natural cell membranes. Int J Pharm. 2022;621:121790.
[36] Oroojalian F, Beygi M, Baradaran B, Mokhtarzadeh A, Shahbazi MA. Immune Cell Membrane-Coated Biomimetic
Nanoparticles for Targeted Cancer Therapy. Small. 2021;17:e2006484.
[37] Wang D, Wang S, Zhou Z, Bai D, Zhang Q, Ai X, et al. White Blood Cell Membrane-Coated Nanoparticles: Recent
Development and Medical Applications. Adv Healthc Mater. 2022;11:e2101349.
[38] Jahromi LP, Shahbazi MA, Maleki A, Azadi A, Santos HA. Chemically Engineered Immune Cell-Derived Microrobots and Biomimetic Nanoparticles: Emerging Biodiagnostic and Therapeutic Tools. Adv sci. 2021;8:2002499.
[39] Lin Z, Wu Y, Xu Y, Li G, Li Z, Liu T. Mesenchymal stem cell-derived exosomes in cancer therapy resistance: recent advances and therapeutic potential. Mol cancer. 2022;21:179.
[40] Matlung HL, Szilagyi K, Barclay NA, van den Berg TK. The CD47-SIRPalpha signaling axis as an innate immune checkpoint in cancer. Immunol Rev. 2017;276:145-64.
[41] Zeng Y, Li S, Zhang S, Wang L, Yuan H, Hu F. Cell membrane coated-nanoparticles for cancer immunotherapy. Acta Pharm. Sin B. 2022;12(8): 3233-3254.
[42] Jan N, Madni A, Khan S, Shah H, Akram F, Khan A, et al. Biomimetic cell membrane‐coated poly(lactic‐co‐glycolic acid) nanoparticles for biomedical applications. Bioeng Transl Med. 2022;7(3):1-20.
[43] Magne TM, de Oliveira Vieira T, Alencar LMR, Junior FFM, Gemini-Piperni S, Carneiro SV, et al. Graphene and its
derivatives: understanding the main chemical and medicinal chemistry roles for biomedical applications. J Nanostructure Chem. 2022;12:693-727.
[44] Zhu L, Zhong Y, Wu S, Yan M, Cao Y, Mou N, et al. Cell membrane camouflaged biomimetic nanoparticles: Focusing on tumor theranostics. Mater Today Bio. 2022;14:100228.
[45] Li P, Wang D, Hu J, Yang X. The role of imaging in targeted delivery of nanomedicine for cancer therapy. Adv Drug Deliv. 2022;189:114447.
[46] Li T, Qin X, Li Y, Shen X, Li S, Yang H, et al. Cell Membrane Coated-Biomimetic Nanoplatforms Toward Cancer
Theranostics. Front Bioeng Biotechnol. 2020;8:371.
[47] Liang S, Liao G, Zhu W, Zhang L. Manganese-based hollow nanoplatforms for MR imaging-guided cancer therapies. Biomater Res. 2022;26:32.
[48] Fu L, Zhang W, Zhou X, Fu J, He C. Tumor cell membrane-camouflaged responsive nanoparticles enable MRI-guided
immuno-chemodynamic therapy of orthotopic osteosarcoma. Bioact Mater. 2022;17:221-33.
[49] Fu LH, Qi C, Hu YR, Lin J, Huang P. Glucose Oxidase-Instructed Multimodal Synergistic Cancer Therapy. Adv Mater Lett. 2019;31:e1808325.
[50] Xie Z, Fan T, An J, Choi W, Duo Y, Ge Y, et al. Emerging combination strategies with phototherapy in cancer nanomedicine. Chem Soc Rev. 2020;49:8065-87.
[51] Zhen X, Cheng P, Pu K. Recent Advances in Cell Membrane-Camouflaged Nanoparticles for Cancer Phototherapy. Small. 2019;15:e1804105.
[52] Lee D, Kwon S, Jang SY, Park E, Lee Y, Koo H. Overcoming the obstacles of current photodynamic therapy in tumors using nanoparticles. Bioact Mater. 2022;8:20-34.
[53] Wang Y, Zhang L, Zhao G, Zhang Y, Zhan F, Chen Z, et al. Homologous targeting nanoparticles for enhanced PDT against osteosarcoma HOS cells and the related molecular mechanisms. J Nanobiotechnology. 2022;20:83.
[54] Mohammad Imran KRP, Saurav Kumar Jha , Philip M Hansbro, Kamal Dua, Yousuf Mohammed. Dressing multifunctional nanoparticles with natural cell-derived membranes for superior chemotherapy. Future Med. 2022;17.
[55] Wu X, Zhang X, Feng W, Feng H, Ding Z, Zhao Q, et al. A Targeted Erythrocyte Membrane-Encapsulated Drug-Delivery System with Anti-osteosarcoma and Anti-osteolytic Effects. ACS applied materials & interfaces. 2021;13:27920-33.
[56] Liu Y, Lei P, Liao X, Wang C. Nanoscale metal–organic frameworks as smart nanocarriers for cancer therapy. J Nanostructure Chem. 2022. https://doi.org/10.1007/s40097-022-00493-2.
[57] Zhang J, Miao Y, Ni W, Xiao H, Zhang J. Cancer cell membrane coated silica nanoparticles loaded with ICG for tumour
specific photothermal therapy of osteosarcoma. Artif Cells Nanomed Biotechnol. 2019;47:2298-305.
[58] Zhang M, Zhang F, Liu T, Shao P, Duan L, Yan J, et al. Polydopamine Nanoparticles Camouflaged by Stem Cell Membranes for Synergistic Chemo-Photothermal Therapy of Malignant Bone Tumors. Int J Nanomedicine. 2020;15:10183-97.
[59] Zhang C, Liu H, Gong M, Yang M, Yang Z, Xie Y, et al. Biomimetic gold nanocages for overcoming chemoresistance of
osteosarcoma by ferroptosis and immunogenic cell death. Mater Des. 2021;210:1-20.
[60] Wang Y, Wang D, Zhang Y, Xu H, Shen L, Cheng J, et al. Tumor Microenvironment-Adaptive Nanoplatform Synergistically Enhances Cascaded Chemodynamic Therapy. Bioact Mater. 2022;22:239-53.
[61] Fu Y, He G, Liu Z, Wang J, Li M, Zhang Z, et al. DNA Base Pairing-Inspired Supramolecular Nanodrug Camouflaged by
Cancer-Cell Membrane for Osteosarcoma Treatment. Small. 2022;18:e2202337.
[62] Cai JX, Liu JH, Wu JY, Li YJ, Qiu XH, Xu WJ, et al. Hybrid Cell Membrane-Functionalized Biomimetic Nanoparticles for
Targeted Therapy of Osteosarcoma. Int J Nanomedicine. 2022;17:837-54.
[63] Chen J, Wu Z, Ding W, Xiao C, Zhang Y, Gao S, et al. SREBP1 siRNA enhance the docetaxel effect based on a bone-cancer dual-targeting biomimetic nanosystem against bone metastatic castration-resistant prostate cancer. Theranostics. 2020;10:1619-32.
[64] Mu X, Zhang M, Wei A, Yin F, Wang Y, Hu K, et al. Doxorubicin and PD-L1 siRNA co-delivery with stem cell membranecoated polydopamine nanoparticles for the targeted chemoimmunotherapy of PCa bone metastases. Nanoscale. 2021;13:8998- 9008.
[65] Kang J, La Manna F, Bonollo F, Sampson N, Alberts IL, Mingels C, et al. Tumor microenvironment mechanisms and bone metastatic disease progression of prostate cancer. Cancer Lett. 2022;530:156-69.
[66] Wong SK, Mohamad NV, Giaze TR, Chin KY, Mohamed N, Ima-Nirwana S. Prostate Cancer and Bone Metastases: The
Underlying Mechanisms. Int J Mol Sci. 2019;20:1-30.
[67] Manna F, Karkampouna S, Zoni E, De Menna M, Hensel J, Thalmann GN, et al. Metastases in Prostate Cancer. Cold Spring Harb Perspect Med. 2019;9: 1-10.
[68] Chugh V, Vijaya Krishna K, Pandit A. Cell Membrane-Coated Mimics: A Methodological Approach for Fabrication,
Characterization for Therapeutic Applications, and Challenges for Clinical Translation. ACS nano. 2021;15:17080-123.
[69] Zhang M, Cheng S, Jin Y, Zhang N, Wang Y. Membrane engineering of cell membrane biomimetic nanoparticles for nanoscale therapeutics. Clin Transl Med. 2021;11:e292. 

Files

History

  • Receive Date: 29 September 2022
  • Revise Date: 23 November 2022
  • Accept Date: 23 November 2022

Share

How to cite

Statistics