Document Type : Review Article


1 Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal

2 Department of Biology, Yadegar-e-Imam Khomeini Shahr-e-Rey Branch, Islamic Azad University; Immunology Board for Transplantation And Cell-based Therapeutics (Immuno_TACT), Universal Scientific Education and Research Network (USERN),

3 Laboratory of Pharmaceutics, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou Guangdong Provincial Key; Laboratory of Chiral Molecule and Drug Discovery, Sun Yat-sen University, Guangzhou

4 Department of Pharmaceutics, Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Pimpri, Pune, Maharashtra, India; Department of Pharmaceutical Sciences, University at Buffalo, State University of New York

5 Faculty of Pharmacy of the University of Coimbra, University of Coimbra, Coimbra, Portugal; Health Sciences Research Centre (CICS-UBI), University of Beira Interior

6 School of Pharmacy Shanghai Jiao Tong University, China


Cancer is a malignant disease of increasing concern on account of its high heterogeneity, high mortality and morbidity rates, as well as absence of targeted and effective therapeutic regimes. The recent introduction of biomimetic and nature-inspired principles in the development of nanosystems has significantly impacted cancer therapies and diagnosis. Biomembrane-surface engineered nanosystems are bioinspired nanoconstructions equipped with cell-mimicking features to improve in vivo interactions with surrounding biological environments and cells. These next-generation nanosized delivery systems can enhance therapeutic efficacy and safety of conventional cancer therapies by providing highly specific, targeted, and safer nanomedicines. Herein, we have discussed the unique features of cell membrane-coated biomimetic nanodevices (including superior biocompatibility, immune evasion and tissue-homing features) that allow for promising osteosarcoma-targeted diagnosis, therapy, and theranostics. We also summarized the recent advances on cell membrane- and hybrid cell membrane-coated nanosystems for both primary bone cancer and metastatic scenarios, especially prostate cancer-derived bone metastases. Future perspectives and challenges towards successful clinical translation are also highlighted.

Graphical Abstract

Cell Membrane-Coated Biomaterials for Bone Cancer-Targeted Diagnosis and Therapy: A Critical Update on Osteosarcoma Applications