Copper benzene 1,3,5-tri carboxylates are widely used in research due to their numerous advantages. With abundant resources, excellent catalytic activity, and relatively simple synthetic procedures, Cu MOFs are ideal for activating starting materials and creating complex structural designs. The tunable conditions promote useful reactions such as oxidation, click chemistry, and Friedel-Crafts alkylation. All these properties make Cu MOFs an excellent choice for scientific research. This review provides an overview of this rapidly evolving research field, highlighting novel Cu3(BTC)2 synthesis strategies and Cu3(BTC)2 applications such as electrochemical sensing and metal ion extraction, energy storage, drug delivery, and its role as a catalyst.