Document Type : Original Article

Authors

• Fatemeh Ghayem
• Shefa Miraninezhad
• Samanesadat Hosseini
• Saied Ali Pourmousavi

School of Chemistry, Damghan University, Damghan, 36716-45667, Iran

Abstract

This study aims to prepare and evaluate the catalytic advantages of ZnFe₂O₄@Fe₃O₄ in the synthesis of 1,8-dioxo-octahydroxanthene derivatives. The catalyst was prepared in two steps (1) preparation of zinc ferrite ZnFe₂O₄ and Fe₃O₄ nanoparticles by co-precipitation technique (2) preparation of mixed metal oxide (ZnFe₂O₄@Fe₃O₄). The catalyst was fully characterized by FTIR, EDX, XRD, FESEM, TGA, and VSM analyses. The ZnFe₂O₄@Fe₃O₄ was applied as a catalyst for the 1,8-dioxo-octahydroxanthenes. The products were synthesized in significant yields (85–95%) in short reaction times (15–60 min) without laborious work-up. The biological activity of 1,8-dioxo-octahydroxant derivatives was studied. These compounds showed antioxidant activity between 64.4 and 90.2% and their antimicrobial activity against S. enterica, E. coli, L. monocytogenes, S. aureus, and E. faecalis was investigated.

Graphical Abstract

Keywords

• ZnFe2O4@Fe3O4
• composite
• 1,8-dioxo-octahydroxanthene
• antioxidant
• antimicrobial